Genetic Chip Technology and Applications

Dragana Đokić; Vladimir Đokić; Željko Stanković; Dalibor Drljača; Siniša Tomić

doi:10.18485/juuntics240101011d

Authors

Dragana Đokić Doctoral student, University “Union – Nikola Tesla”, Belgrade, Serbia Author https://orcid.org/0000-0002-9206-2764
Vladimir Đokić Doctoral student, University “Union – Nikola Tesla”, Belgrade, Serbia Author https://orcid.org/0009-0004-9678-6999
Željko Stanković Faculty of Informatics and Computer science, University Union—Nikola Tesla, Belgrade, Serbia Author
Dalibor Drljača Faculty of Information Technologies, Pan-European Aperion University, Banja Luka, Bosnia and Herzegovina Author
Siniša Tomić Faculty of Information Technologies, Pan-European Aperion University, Banja Luka, Bosnia and Herzegovina Author

DOI:

https://doi.org/10.18485/juuntics240101011d

Keywords:

Genetic chips, DNA, RNA, biotechnology

Abstract

Gene chips are widely used in animal and plant science. Generally, microarrays are of two types, cDNA or oligonucleotide, cDNA was developed at Stanford University, while oligonucleotides were developed by Affymetrix. We will explore genetic chips, the technology used for their production and reading, and their applications. Gene chips, which are becoming increasingly popular throughout the field of molecular biology and biotechnology, are a recently developed technique that provides efficient access to genetic information using miniaturized high-density arrays of DNA or oligonucleotide probes. Both fundamental and applied research benefit greatly from the specific advantages of this method. There are several steps in the design and implementation of DNA chip technology: probe generation, chip fabrication, sample preparation, analysis, readout, and software. At present, the main application of large-scale microarrays is comparative expression analysis. Microarray technology allows for the analysis of expression profiles for thousands of genes in parallel. One of the most significant applications of this technique is gene expression and profiling on a genome-wide scale. Genechip technology is a new technique that will undoubtedly significantly increase the speed of molecular biology research.

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